Our T cell Antigen Coupler (TAC) platform uses patient-derived T cells.

Our Autologous Approach

Our lead autologous product, TAC101-Claudin 18.2, is designed to target Claudin 18.2-expressing tumors. We will pursue various other novel targets with an autologous approach.

A truly scalable technology for automating cell therapy manufacturing.

Given the current challenges of existing autologous therapies, we have entered a risk-sharing collaboration with Lonza to use their Cocoon™ Manufacturing System. It effectively bypasses many of the industry-standard manual steps in product production by streamlining sample processing.

We believe the Cocoon will enable us to deliver a high-quality TAC101-Claudin 18.2 cell therapy product for each patient in need.
  • Improved Quality and Reproducibility
  • Decreased Footprint for Manufacturing at Scale
  • Decreased Cost of Goods
  • Broad Geographical Distribution

How it Works

Sample
Collection

Sample
Preparation

Selection
(optional)

Activation

Transduction

Expansion

Formulation

Patient
Admin

Sample
Collection

Sample
Preparation

Selection
(optional)

Activation

Transduction

Expansion

Formulation

Patient
Admin

Cocoon eliminates six major manual steps

Cocoon eliminates six major manual steps

Future development and programs.

Our lead autologous product, TAC101-Claudin 18.2, is designed to target Claudin 18.2-expressing tumors. However, we intend to pursue various other cancer targets with an autologous approach, including Claudin 18.2, GPC3 and GUCY2C.