Scientific Presentations & Publications

The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Aug 3, 2018

Helsen CW, Hammill JA, Lau VWC, Mwawasi KA, Afsahi A, Bezverbnaya K, Newhook L, Hayes DL, Aarts C, Bojovic B, Denisova GF, Kwiecien JM, Brain I, Derocher H, Milne K, Nelson BH, Bramson JL. The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Nature Communications. 2018;9:3049. doi:10.1038/s41467-018-05395-y. PMC. Web. 21 Aug. 2018. PMID: 30076299

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Tumor-targeting domains for chimeric antigen receptor T cells

Dec 21, 2016

Bezverbnaya K, Mathews A, Sidhu J, Helsen CW, Bramson JL. Tumor-targeting domains for chimeric antigen receptor T cells. Immunotherapy. 2017 Jan;9(1):33-46. doi: 10.2217/imt-2016-0103. Review. PubMed PMID: 28000526.

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Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes

Sep 1, 2016

Hammill JA, Afsahi A, Bramson JL, Helsen CW. Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes. Methods Mol Biol. 2016;1458:137-57. doi: 10.1007/978-1-4939-3801-8_11. PubMed PMID: 27581020.

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Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors

Dec 15, 2015

Hammill JA, VanSeggelen H, Helsen CW, Denisova GF, Evelegh C, Tantalo DG, Bassett JD, Bramson JL. Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors. J Immunother Cancer. 2015 Dec 15;3:55. doi: 10.1186/s40425-015-0099-4. eCollection 2015. PubMed PMID: 26673402; PubMed Central PMCID: PMC4678647.

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Chimeric antigen receptor-engineered T cells as oncolytic virus carriers

Sep 9, 2015

VanSeggelen H, Tantalo DG, Afsahi A, Hammill JA, Bramson JL. Chimeric antigen receptor-engineered T cells as oncolytic virus carriers. Mol Ther Oncolytics. 2015 Sep 9;2:15014. doi: 10.1038/mto.2015.14. eCollection 2015. PubMed PMID:27119109; PubMed Central PMCID: PMC4782951.

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T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

Jul 21, 2015

VanSeggelen H, Hammill JA, Dvorkin-Gheva A, Tantalo DG, Kwiecien JM, Denisova GF, Rabinovich B, Wan Y, Bramson JL. T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice. Mol Ther. 2015 Oct;23(10):1600-10. doi: 10.1038/mt.2015.119. Epub 2015 Jun 30. PubMed PMID: 26122933; PubMed Central PMCID: PMC4817919.

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