Scientific Presentations & Publications
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
Aug 3, 2018
Helsen CW, Hammill JA, Lau VWC, Mwawasi KA, Afsahi A, Bezverbnaya K, Newhook L, Hayes DL, Aarts C, Bojovic B, Denisova GF, Kwiecien JM, Brain I, Derocher H, Milne K, Nelson BH, Bramson JL. The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Nature Communications. 2018;9:3049. doi:10.1038/s41467-018-05395-y. PMC. Web. 21 Aug. 2018. PMID: 30076299
Tumor-targeting domains for chimeric antigen receptor T cells
Dec 21, 2016
Bezverbnaya K, Mathews A, Sidhu J, Helsen CW, Bramson JL. Tumor-targeting domains for chimeric antigen receptor T cells. Immunotherapy. 2017 Jan;9(1):33-46. doi: 10.2217/imt-2016-0103. Review. PubMed PMID: 28000526.
Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes
Sep 1, 2016
Hammill JA, Afsahi A, Bramson JL, Helsen CW. Viral Engineering of Chimeric Antigen Receptor Expression on Murine and Human T Lymphocytes. Methods Mol Biol. 2016;1458:137-57. doi: 10.1007/978-1-4939-3801-8_11. PubMed PMID: 27581020.
Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors
Dec 15, 2015
Hammill JA, VanSeggelen H, Helsen CW, Denisova GF, Evelegh C, Tantalo DG, Bassett JD, Bramson JL. Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors. J Immunother Cancer. 2015 Dec 15;3:55. doi: 10.1186/s40425-015-0099-4. eCollection 2015. PubMed PMID: 26673402; PubMed Central PMCID: PMC4678647.
Chimeric antigen receptor-engineered T cells as oncolytic virus carriers
Sep 9, 2015
VanSeggelen H, Tantalo DG, Afsahi A, Hammill JA, Bramson JL. Chimeric antigen receptor-engineered T cells as oncolytic virus carriers. Mol Ther Oncolytics. 2015 Sep 9;2:15014. doi: 10.1038/mto.2015.14. eCollection 2015. PubMed PMID:27119109; PubMed Central PMCID: PMC4782951.
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice
Jul 21, 2015
VanSeggelen H, Hammill JA, Dvorkin-Gheva A, Tantalo DG, Kwiecien JM, Denisova GF, Rabinovich B, Wan Y, Bramson JL. T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice. Mol Ther. 2015 Oct;23(10):1600-10. doi: 10.1038/mt.2015.119. Epub 2015 Jun 30. PubMed PMID: 26122933; PubMed Central PMCID: PMC4817919.