Benjamin L. Schlechter, MD, on Addressing Unmet Needs in HER2 Positive Solid Tumors

October 31, 2022

“There’s sort of 2 big groups of HER2 solid tumors: there’s the breast cancer population, and there’s everybody else. The reality in breast cancers is there’s a myriad of effective treatments: cytotoxics, antibody-drug conjugates, combinations, monoclonal antibodies, and targeted therapies. And those have had much less benefit in other HER2-positive malignancies… HER2 therapy has not been as effective in GI malignancies and other malignancies as it has been in breast cancer.”

While commercially available treatment options have shown efficacy in treating HER2-positive solid tumors in patients with breast cancer, these same treatments have been less effective in treating patients with HER2-positive solid tumors in other types of cancers, such as gastrointestinal (GI) malignancies.

Benjamin L. Schlechter, MD, instructor, medicine, Harvard Medical School, and Dana-Farber Cancer Institute, recently presented data from the ongoing phase 1/2 TACTIC-2 clinical trial (NCT04727151) of TAC01-HER2, an investigational HER2-targeted T-cell antigen coupler (TAC) T-cell therapy intended to address unmet needs for patients with HER2-positive solid tumors, at the European Society for Medical Oncology (ESMO) Congress 2022, taking place September 9-13, in Paris, France, and virtually.